Section Topics and Session Titles

Main topics of the ISER Meeting

Section Topics

Glaucoma

The GL section has assembled 13 sessions that are focused on key areas of research exploring the basic pathological mechanisms of glaucoma plus cutting edge diagnostic and treatment strategies.  Two of our sessions are dedicated to discussing the genetics that underlie susceptibility for different forms of glaucoma, including primary open-angle, angle closure and exfoliation.  Three of our sessions are focused on novel therapeutic strategies for glaucoma including drug delivery, gene therapy, and cellular-based treatments.  The bulk of our sessions (7) are programmed to explore the complicated pathological mechanisms that underlie glaucomatous damage at the level of the optic nerve head plus the molecular and cellular mechanisms in the conventional outflow tract that regulate intraocular pressure.

Lens

Our sense of sight is critically dependent on the ability of the lens to correctly focus light onto the retina. To achieve this feat the lens needs to maintain its refractive and transparent properties over many decades of life. The age dependent loss of these functions results initially in presbyopia in middle age, and in the elderly, lens cataract - the leading cause of blindness in the world today. To advance our understanding of how the lens establishes and maintains its optical properties and how these properties are impaired in presbyopia and cataract, an exciting lens section has been developed. The program will include sessions on lens development and regeneration, the cellular biology and physiology of the normal lens and how the integrated cellular structure and function of the lens contributes to its overall optical properties. These sessions will be complemented by sessions that focus on the causes of presbyopia and underlying pathology of lens cataract, including secondary cataract or posterior capsular opacification.

Cornea and Ocular Surface

The corneal section has put together ten distinct sessions on the cornea and ocular surface covering a broad range of topics including clinical, basic-science and translational research. Invited speakers are all internationally recognized andare well-known experts in their field. Subjects covered will include new advancements in the areas of corneal and ocular surface infection, corneal epithelium, endothelial cells, stromal repair, refractive surgeries, regenerative biology, and basic biology. Each of the corneal sessions have been organized to provide an excellent opportunity to receive contributions from younger (in-training) corneal clinical and basic scientists. Up to 15 of such scientists will be chosen from the submitted abstracts to present their work as an oral presentation to their peers and leaders in corneal biology and repair. The sessions are specifically designed to promote both cutting-edge corneal research and interactions among young-and-established investigators thus creating an environment for great networking opportunities.

Ocular Immunology

Over the past several years the field of ocular immunology has experienced a resurgence of interest. From mechanisms of innate immune surveillance to control of adaptive immune responses, new molecules have been identified as pivotal in disease pathophysiology and novel targets for disease treatment have been identified. The immunologic contributions to disease are now better understood for conditions such as uveitis, age-related macular degeneration (AMD) and diabetic retinopathy. The immunology sessions at ISER will highlight these areas of advancement and introduce cutting edge and innovative approaches to answer some of the more challenging questions in the field. Thought leaders will present original work from their laboratories and concepts that are applicable to many aspects of vision science. Topics will include: immunopathogenic mechanisms and novel treatments for uveitis and other inflammatory ocular disorders, the roles of resident microglia and recruited macrophages in progression of ocular diseases, how the retinal pigmented epithelium (RPE) forms an immune-suppressive barrier and controls complement cascade in the retina, and the role of fibrotic responses in inflammatory eye diseases.

Ocular Imaging

The ocular imaging section has assembled 6 sessions attracting worldwide leaders in the field of vision sciences, clinical imaging as well as imaging technology development. These sessions are focused on imaging in glaucoma and myopia, OCT angiography including quantitative Doppler OCT, adaptive optics in clinical and vision sciences, functional and contrast enhanced ocular imaging as well as new cutting edge advances in numerous emerging imaging technologies. Overall the ocular imaging section gives state of the art insight in a variety of established, recently emerged as well as potentially future diagnostic techniques in ophthalmology.

Retinal Cell Biology

The Retinal Cell Biology section bridges the gap between mechanistic investigation of cellular processes and the pathological changes in retinal disease. Led by the leaders from their prospective fields, the presentations will integrate recent findings on retinal function with the growing understanding of pathology and provide succinct updates in several fast moving fields. For example, sessions on “Signal Transduction in the Retina” and “Retinoids in Vision” provide updates on the biochemical aspects of phototransduction while “Assembly and Maintenance of the Phototransduction Organelle” will address the structural elements. Insight into age related degeneration (AMD) is provided by sessions on “Inflammation in AMD” and “Oxidative and ER Stress in Retinal Degenerations” while the session on “New insights on the RPE/Bruchs membrane/choriocapillaris in AMD” provides new information about the choroidal contributions to the disease. These mechanistic approaches are complemented by a session on “Modeling AMD: Mouse to Man” and “Understanding Diabetic Retinopathy and AMD through animal models”. The session on “Retinopathy of Prematurity” will cover key developments within this disease. Together, the nine sessions will highlight the most critical advances in the field of retinal cell biology and encourage active discussions among all ISER attendees.

 

Retinal Cell Biology

The Retinal Cell Biology section bridges the gap between mechanistic investigation of cellular processes and the pathological changes in retinal disease. Led by the leaders from their prospective fields, the presentations will integrate recent findings on retinal function with the growing understanding of pathology and provide succinct updates in several fast moving fields. For example, sessions on “Signal Transduction in the Retina” and “Retinoids in Vision” provide updates on the biochemical aspects of phototransduction while “Assembly and Maintenance of the Phototransduction Organelle” will address the structural elements. Insight into age related degeneration (AMD) is provided by sessions on “Inflammation in AMD” and “Oxidative and ER Stress in Retinal Degenerations” while the session on “New insights on the RPE/Bruchs membrane/choriocapillaris in AMD” provides new information about the choroidal contributions to the disease. These mechanistic approaches are complemented by a session on “Modeling AMD: Mouse to Man” and “Understanding Diabetic Retinopathy and AMD through animal models”. The session on “Retinopathy of Prematurity” will cover key developments within this disease. Together, the nine sessions will highlight the most critical advances in the field of retinal cell biology and encourage active discussions among all ISER attendees.

 

Retinal Neuroscience and Development

The focus of the Retinal Neuroscience and Development section is the analysis of molecular and genetic mechanisms that control the specification of retinal cells types, the assembly of retinal circuitry, the pathology of retinal dystrophies, and regenerative approaches to treating these disorders.  Sessions within this section will highlight recent developments in our understanding of intrinsic and extrinsic mechanisms that determine retinal cell identity, and also progress in regenerative approaches to replacement of damaged photoreceptors and ganglion cells.  Likewise, the latest progress in our understanding of the development and function of retinal circuitry will be presented together with advances in inducing axonal regeneration in retinal ganglion cells.   Sessions on molecular mechanisms of neuroprotection, animal and organoid models of human disorders, and stem cell-based therapies for photoreceptor dystrophies will present the latest advances in the treatment of retinal disease.  Special sessions will focus on late-breaking developments in the areas of the role of noncoding RNAs in retinal development and disease, and control of calcium signaling in retinal physiology.

Ocular Pharmacology and Therapeutics

Ocular Pharmacology and Therapeutics section has put together over ten sessions that address new drugs, targets, mechanisms, drug delivery, gene delivery, biomarkers, and barriers to clinical translation of new ocular therapeutic agents. The topics will address diseases of the front as well as the back of the eye. These sessions will feature renowned invited speakers from industry as well as academia. Additionally, several speakers including young scientists will be selected to address emerging hot topics based on the abstracts submitted.

Ophthalmic Genomics

Recent advances in genetics and genomics enable to gain deeper understanding of the genome, transcriptome and epigenome in health and disease. The tools and technologies that are currently available to modify and study the genome provides exciting opportunities to understand the basic biological processes and apply the knowledge to develop personalized and more effective therapies it treat diseases. The ‘Genetics and Genomics’ section includes sessions on a wide range of topics in ophthalmic genetics focused on understanding the impact of the genome composition on normal biological processes and its role in health and disease of the eye.

Session Titles

Glaucoma

Restoring Conventional Outflow
ONH/NFL imaging in glaucoma
Translaminar pressure gradient and glaucoma progression
Biomechanics of glaucoma
Genetics of glaucoma
Biology of the TM
Distal Outflow Resistance: Towards Understanding MIGS
Status of glaucoma gene and stem cell therapy
Lymphangiogenesis, Lymphatics and IOP Regulation

Lens

Lens Development
Oxidative Stress
Biomarkers in Cataractogenesis
Lens Regeneration and Evolution
Channels and Transporters
Animal Models of Cataract
Lens Cytoskeleton
Post-translational modification of crystallins
PCO/EMT
The Zonule of Zinn: biology and pathology
Alpha crystallins and small heat-shock proteins
Physiological Optics

Cornea and Ocular Surface

Corneal Infection
Emerging paradigms in stromal regenerative biology
Corneal Endothelium: Pathophysiology and Treatment
Corneal Refractive Surgeries
Cornea Transplantation and keratoprothesis
Keratoconus biology and treatment
New Diagnosis and Therapies for Corneal Diseases
Ocular Surface Epithelial Homeostasis (Conjunctival, Limbal, Corneal)
Reimbursement of Ocular Surface Cell Based therapies -Bottlenecks in Bioprocessing
Dry Eye

Ocular Immunology

New molecular mechanisms and therapeutic approaches for uveitis
RPE regulation of innate immune activity and functionality in macrophages
An intersection of receptor signaling pathways with neuroinflammation (inflammasome)
RPE and Inflammation
Microglia and macrophages as therapy targets for retinal diseases

Ocular Imaging

New advances in ocular imaging - part I
New advances in ocular imaging - part II
OCT angiography
Functional imaging
Shuliang
Imaging in glaucoma and myopia

RPE Choroid Biology and Pathology

Making RPE from Stem Cells
Lipid dynamics at the photoreceptor-RPE nexus
The Next Best thing: Making sense of the bestrophinopathies
New approaches towards clinical endpoints in diabetic retinopathy
VEGF and beyond
Inflammasomes in the RPE
Metabolic Coupling in the outer retina
Exploring the intersection between inflammation and lipid metabolism in age-related macular degeneration
RPE regulation of innate immune activity and functionality in macrophages
Functional Genome of the Retinal Pigment Epithelium
Aging RPE: Proteostasis mechanisms in health and diseases
Lymphatics and fluid movement in the posterior eye: Recent advances and remaining controversies
RPE dysfunction in AMD: from oxidative damage to inflammasome activation

Retinal Cell Biology

New insights on the RPE/Bruchs membrane/choriocapillaris in AMD
Inflamation in AMD
Retinopathy of Prematurity
Signal Transduction in the Retina
Assembly and Maintenance of the Phototransduction Organelle
Oxidative and ER Stress in Retinal Degenerations
Modeling AMD: Mouse to Man
Retinoids in vision
Understanding Diabetic Retinopathy and AMD through animal models

Retinal Neuroscience and Development

Transcription control of retinal cell identity
Epigenetics in development and disease
Cell-cell signaling and retinal development
Establishment of retinal circuitry and synapses
Retinal circuitry and visual signal processing
RGC axonal targeting and regeneration
Retinal regeneration through controlled dedifferentiation
Mechanisms of neuroprotection
Modeling human retinal disease
ES/iPS-based approaches to treating retinal dystrophies
Noncoding RNA in retinal development and disease
Ca++ signaling in retinal ganglion cells and outer retinal neurons

Ocular Pharmacology and Therapeutics

Translational studies in glaucoma-How do we make basic science studies in glaucoma more clinically relevant: development of a consensus
Translational ophthalmology: Novel targets and their development into the clinic
Sustained drug delivery approaches for enhanced glaucoma therapy
Blue light and circadian system
An intersection of receptor signaling pathways with neuroinflammation (inflammasome)
Matching clinical needs and novel drug delivery systems for the posterior segment of the eye
Novel molecular mechanisms of diabetic retinopathy
Therapeutic targets for retinal dissease: Lessons learnt form bench side
New molecular mechanisms and therapeutic approaches for uveitis
Dry eye diagnosis
Imaging biomarkers for retinal diseases
Gene delivery to the eye
TBI (traumatic brain injury: Visual dysfunction and treatment
Prostaglandins for Ocular Hypertension Treatment: A new Era is Dawning
Sphingolipids in Ocular Diseases
Molecular mechanisms of fibrosis in eye tissues

Ophthalmic Genomics

Genetics of multifactorial eye diseases
Congenital stationary night blindness from A-Z
Asian eye genetics
Genetics of normal tension glaucoma
Epigenetic Modifications And Non-Coding RNAs In The Ocular Health and Disease
An omics perspective on pediatric eye diseases
Genetics of cataracts
Genetics of corneal dystrophies
Next generation technology in eye genetics
Genomics of ophthalmic diseases
Retinal dystrophy
Genetics of myopia
Current concept in genetics of hereditary ocular developmental anomalies

Independent Sessions

Autophagy in eye health and disorders
Electrophysiology of Vision
Oxidative Stress in Ocular Tissue
Cell-signaling in anterior segment development and dieases
Meibomian Glands and Meibum - From Biochemistry to Physiology to Disease
Expanding the functions of ocular surface innevation: photophobia and photoallodynia
Plasticity in the Visual System
Innate mechanisms that contribute to RPE pathology

 

 

Program Committee

ISER 2016 Program CommitteeProgram ChairAffiliationCountry
  Takeshi Iwata National Institute of Sensory Organs, Tokyo Medical Center, National Hospital Organization Japan
  Takahisa Furukawa Institute for Protein Research, Osaka University Japan
SectionMemberAffiliationCountry
Glaucoma Ernst Tamm Institute of Human Anatomy & Embryology, University of Regensburg Germany
Glaucoma W. Daniel Stamer Department of Ophthalmology, Duke University USA
Glaucoma Makoto Araie Kanto Central Hospital and The University of Tokyo Japan
Lens Frank J. Lovicu Save Sight Institute and Bosch Institute, The University of Sydney Australia
Lens Paul Donaldson Faculty of Medical and Health Sciences, The University of Auckland New Zealand
Lens Shizuya Saika Department of Ophthalmology, Wakayama Medical University Japan
Cornea and Ocular Surface Koji Nishida Department of Ophthalmology, Osaka University Japan
Cornea and Ocular Surface Rajiv R. Mohan Department of Ophthalmology and Molecular Medicine, University of Missouri USA
Cornea and Ocular Surface Che J. Connon Institute of Genetic Medicine, University of Newcastle UK
Ocular Immunology Lynn K. Gordon Jules Stein Eye Institute, UCLA USA
Ocular Immunology Steven F. Abcouwer Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center USA
Ocular Imaging Wolfgang Drexler School of Optometry and Vision Sciences, Medical University of Vienna  Austria
Ocular Imaging Yoshiaki Yasuno Faculty of Pure and Applied Sciences, Tsukuba University Japan 
Ocular Imaging James G. Fujimoto Department of Electrical Engineering and Computer Science, MIT USA
Ocular Imaging Joel S. Schuman Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine USA
RPE Choroid Biology and Pathology Kathleen Boesze-Battaglia Department of Biochemistry, University of Pennsylvania USA
RPE Choroid Biology and Pathology Stephen Moss Faculty of Brain Sciences, Institute of Ophthalmology, University College London UK
RPE Choroid Biology and Pathology Olaf Strauss Experimental Ophthalmology Eye-Hospital, University Hospital Regensburg Germany
Retinal Cell Biology Vadim Y. Arshavsky Duke Institute for Brain Sciences, Duke University USA
Retinal Cell Biology Claire H. Mitchelle Department: Anatomy & Cell Biology, University of Pennsylvania USA
Retinal Cell Biology Gerard A. Lutty Wilmer Eye Institute, Johns Hopkins University USA
Retinal Neuroscience and Development Xian-Jie Yang Brain Research Institute, University of Calfornia, Los Angeles USA
Retinal Neuroscience and Development Seth Blackshaw Department of Neuroscience, Johns Hopkins University USA
Ocular Pharmacology and Therapeutics Uday B. Kompella Department of Pharmaceutical Sciences, University of Colorado USA
Ocular Pharmacology and Therapeutics Filippo Drago Department of Biomedical and Biotechnological Sciences, Catania University Italy
Ocular Pharmacology and Therapeutics Cheryl Rowe-Rendleman Ophthalmic Medical & Research Consultants USA
Ophthalmic Genomics Radha Ayyagari University of Calfornia San Diego USA
Ophthalmic Genomics Takeshi Iwata National Institute of Sensory Organs, Tokyo Medical Center, National Hospital Organization Japan
  Debasish Sinha Wilmer Eye Institute, Johns Hopkins University USA
  Mineo Kondo Department of Ophthalmology, Mie University Japan